Inside Cover: From Reactivity and Regioselectivity to Stereoselectivity: An Odyssey of Designing PIP Amine and Related Directing Groups for C—H Activation (Chin. J. Chem. 7/2019)

Abstract

The inside cover picture shows the journey of developing PIP amine directing group for C—H activation, from controlling the reactivity and diastereoselectivity to enantioselectivity. In the presence of Pd or base metal catalysts, PIP amine enabled the activation of inert C—H bonds to form diverse C—C and C—heteroatom bonds. Its tuneable structure has triggered the design of chiral auxiliaries for diastereoselective C—H activation. More recently, enantioselective activation of unbiased methylene C—H bonds has been achieved by cooperative effects between PIP amine and axial chiral ligands. More details are discussed in the article by Shi et al. on page 647–656. image