Abstract
A series of thioacids is described as hydrogen sulfide prodrugs by B. Wang et al. in their Communication on page 4514 ff. The release takes advantage of a “trimethyl lock”-facilitated lactonization controlled by an esterase trigger that unmasks a hydroxy group as the attacking nucleophile. These hydrogen sulfide prodrugs are stable under physiological conditions and release H2S with tunable release rates by modifying the ester group.
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