Inside Cover: Designer Outer Membrane Protein Facilitates Uptake of Decoy Molecules into a Cytochrome P450BM3‐Based Whole‐Cell Biocatalyst (Angew. Chem. Int. Ed. 7/2022)

Abstract

A loop deletion mutant of outer membrane protein F (OmpF) that facilitates the cellular uptake of decoy molecules into Escherichia coli has been developed. In their Communication (e202111612), Osami Shoji and co-workers report that co-expression of the OmpF mutant with wild-type CYP102A1 enables an E. coli-based whole-cell biocatalyst to efficiently oxidise benzene, alkyl- and cycloalkylbenzenes with the help of decoy molecules, bringing this system a significant step closer to practical applications.