Inside Cover: Deciphering the Metal Speciation in Low‐Molecular‐Weight Complexes by IMS‐MS: Application to the Detection of Manganese Superoxide Dismutase Mimics in Cell Lysates (Angew. Chem. Int. Ed. 38/2022)

Abstract

Within the crowded cell environment , Mn-based superoxide dismutase (SOD) mimics were detected and quantified, with an analogous [13C6LCoII] (L=ligand) as a standard, in intricate cell lysates by using ion mobility spectrometry coupled to mass spectrometry (IMS-MS). In their Research Article (e202203066), Clotilde Policar and co-workers show that IMS is powerful enough to separate complexes of the same ligand bound to different divalent metal cations with similar ionic radii. In timsTOF, ions are pushed by the gas flow, retained electrostatically, and as represented in the picture, the smaller, the slower.