Abstract
DNA Condensation The condensation of DNA in a controlled manner is one of the key steps in gene delivery and gene therapy. As described in their Full Paper on page 1895 ff., Yu Liu and co-workers designed and constructed a water-soluble and nontoxic nanometer-sized conjugate comprising gold nanoparticles, β-cyclodextrins, and anthryl adamantanes (see the Inside Cover). This conjugate exhibits a good condensation ability toward DNA through the intercalation of the anthryl groups into the DNA double helix. Significantly, the condensation efficiency of the supramolecular nanostructure towards DNA could be conveniently controlled by adjusting the ratio between gold nanoparticles and anthryl adamantane grafts.
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