Inside Cover: Background‐Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation (Angew. Chem. Int. Ed. 50/2021)

Abstract

Radiofrequency amplification by stimulated emission radiation (RASER) is the version of lasers and masers operating in the radiofrequency spectral range. In their Communication on page 26298, Eduard Y. Chekmenev and co-workers employ 61 MHz proton RASER to demonstrate robust background-free detection of biomolecular NMR resonances even in the extreme cases of fully protonated solvents and biological fluids. This approach paves the way to a wide range of high-resolution NMR and in vivo MRI applications of background-free proton detection of hyperpolarized molecules.