Abstract
The selective N-acylation of glucosamine with unprotected carboxylic acids enables the biosynthesis of unnatural glycosides and their subsequent enzymatic modification. In their Communication on page 5308, L. Liu, S. L. Flitsch, J. Voglmeir et al. report that the enzyme chitobiose deacetylase from Cyclobacterium marinum has promiscuous N-acylation activity without the need for activation of the acid. This selective N-acylation step provides the last missing link for the fully enzymatic multistep synthesis of C5-modified sialosides from chitin.
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