Abstract
All-nitrogenated sugars (ANSs), in which all hydroxy groups in a carbohydrate are replaced with amino groups, are anticipated to be privileged structures with useful biological activities. In their Communication on page 5193, Takaaki Sato, Noritaka Chida, and co-workers report the synthesis, transformation, and biological tests of ANS derivatives. The key to success was a seven-step synthesis of ANSs by a sequential Overman rearrangement enabling formal simultaneous substitution of four or five hydroxy groups in monosaccharides with amino groups.
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