Abstract
The inside-back cover picture shows the importance of unpaired terminal nucleotides (dangling ends) in RNA duplexes. Under cell-mimicking conditions, the extent to which RNA duplexes with dangling ends are destabilized is dependent on the hydration state of the dangling ends. In contrast, RNA duplexes with dangling ends are stabilized in vitro conditions. It has been postulated that dangling ends alone stabilize helices; however, our results suggest that stabilization is responsive to the surrounding conditions. For more details, see the Full Paper by Naoki Sugimoto et al. on p. 2150 ff.
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