Abstract
Overcoming drug resistance in malaria parasites against available drugs is possible by using drug hybrids, as reported by S. B. Tsogoeva, L. Ackermann, J. Wang, and co-workers in their Research Article on page 13066 ff. The merging of two differently acting drugs (e.g., artemisinin and chloroquine) in one hybrid compound gives simultaneous cellular uptake of the pharmacophore components of the hybrid, and dual action is achieved, thereby enabling novel functions targeting pathogens, multidrug resistance.
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