Inside Back Cover: An Enzyme‐Activatable Engineered DNAzyme Sensor for Cell‐Selective Imaging of Metal Ions (Angew. Chem. Int. Ed. 12/2021)

Abstract

Cell-selective imaging of metal ions was achieved by Lele Li and co-workers in their Communication on page 6300 by using an enzyme-activatable DNAzyme sensor technology. In the picture, the sensing activity is silent in normal cells and can be restored by an overexpressed enzyme in cancer cells through site-specific cleavage. The DNAzyme sensor allowed distinguishing metal-ion signals in tumor cells from healthy cells both in vitro and in vivo.