Abstract
Cell-selective imaging of metal ions was achieved by Lele Li and co-workers in their Communication on page 6300 by using an enzyme-activatable DNAzyme sensor technology. In the picture, the sensing activity is silent in normal cells and can be restored by an overexpressed enzyme in cancer cells through site-specific cleavage. The DNAzyme sensor allowed distinguishing metal-ion signals in tumor cells from healthy cells both in vitro and in vivo.
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