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Abstract
A series of cyclic pseudopeptides were synthesized containing the sequence -Trp-Phe-( d)-PheΨCH 2NH-, the terminal ends of which were bound to 2-carboxy succinate or enantiomerically enriched tricarballylic acid to give the final cyclic structures. These two molecules and their subsequent derivatives were screened for h-NK2 receptor binding and functional antagonist activity on the rabbit urinary bladder.
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