Abstract
Serum concentrations of LH were measured daily by radioimmunoassay throughout the menstrual cycles of 8 rhesus monkeys ( Macaca mulatta). A midcycle LH surge was observed in all animals studied on days 10 to 17 (mean 13.5) of the cycle with an increase of 2- to 7-fold (mean 5) from the levels of follicular and luteal phase. The apparent ovulation was confirmed by the increase of serum progesterone after midcycle LH surge in all animals. The effect of synthetic LH-releasing factor (LRF) on the release of LH was then studied in 7 rhesus monkeys with different endocrine milieu, but no detectable response was observed with a single intravenous administration of 1 to 50 g which has been shown to be effective in humans. This disparity was unexpected and suggests a species difference in responsiveness to the synthetic decapeptide between monkeys and humans.
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