Abstract
Culex quinquefasciatus is a vector of lymphatic filariasis and vector control strategies normally involve the use of synthetic insecticides targeted against them. Extensive and uncontrolled use of these synthetic insecticides has led to the development of insecticide resistance in the mosquito vectors. In this context, to study the resistance status of Cx. quinquefasciatus, field populations were collected from three districts of Northern part of West Bengal and tested against insecticides (5% malathion, 0.05% deltamethrin, 0.05% lambdacyhalothrin,0.75% permethrin, 0.1% propoxur, 4% DDT and Temephos). Qualitative and quantitative enzyme assay was also conducted in order to find the role of detoxifying enzymes behind the development of insecticide resistance. This study revealed the presence of widespread resistance amongst the field populations of Cx. quinquefasciatus throughout the studied regions. Moreover, the result of native PAGE and biochemical enzyme assay may be linked to some extent in the involvement of the detoxifying enzymes in conferring resistance against insecticides in most of the tested Cx. quinquefasciatus populations. The present study involving the survey of resistance status may be of immense help during the implementation of vector control strategies throughout this region.
Highlights
Vector-borne diseases are associated with major public health problems, mainly in the tropical and sub-tropical countries due to favourable climatic condition for the growth and proliferation of insect vectors and lack of proper sanitation
Mortality of field population larvae in NVBDCP recommended dose varied as 4 of the tested populations i.e., BDN, JPT, FLB and CPR showed susceptibility towards temephos with cent percent mortality while DPG and ISL population showed intermediate resistance towards temephos with mortality percentage of 94.30 and 92.30 respectively and SLG population was resistant with 88.20% mortality rate
LC50 values of the studied population ranged from 0.001–0.011 ppm with a maximum of 10 fold higher values when compared to LC50 value of SP (Table 1)
Summary
Vector-borne diseases are associated with major public health problems, mainly in the tropical and sub-tropical countries due to favourable climatic condition for the growth and proliferation of insect vectors and lack of proper sanitation. Mosquitoes are responsible for many dreaded tropical diseases like dengue fever, malaria, lymphatic filariais, west nile fever, Japanese encephalitis, chikungunya, yellow fever, zika, etc causing several million deaths and medical cases around the globe [1]. In the absence of proper treatment, some of these diseases may prove to be fatal while others might leave the patient with lifelong disability and impairment. Insecticide resistance mapping in Culex quinquefasciatus Say
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