Abstract
A bioactivity-directed investigation of an extract of the New Zealand clubmoss, Lycopodium varium, collected on subantarctic Campbell Island, has led to the isolation of the alkaloid huperzine A (1) as the major antifeedant and insecticidal component. Huperzine A showed insecticidal activity against the Australian carpet beetle, Anthrenocerus australis (LD(50) = 110 ppm), the Australian sheep blowfly, Lucilia cuprina (LD(50) = 2380 ppm), and the webbing clothes moth, Tineola bisselliella (LD(50) = 630 ppm). Feeding by A. australis was reduced by 97% at 63 ppm.
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