Abstract
A great deal of attention has been focused on the secondary metabolites produced by marine endophytic fungi, which can be better alternatives to chemicals, such as biopesticides, for control of polyphagous pests. On the basis of its novel biocontrol attributes, chemical investigation of a marine alga-derived endophytic fungus, Acremonium vitellinum, resulted in the isolation of three chloramphenicol derivatives (compounds 1–3). Their chemical structures were elucidated by detailed analysis of their nuclear magnetic resonance spectra, high-resolution electrospray ionization mass spectrometry, and by comparison with the data available in the literature. In this paper, compound 2 was firstly reported as the natural origin of these fungal secondary metabolites. The insecticidal activities of compounds 1–3 against the cotton bollworm, Helicoverpa armigera, were evaluated. The natural compound 2 presented considerable activity against H. armigera, with an LC50 value of 0.56 ± 0.03 mg/mL (compared to matrine with an LC50 value of 0.24 ± 0.01 mg/mL). Transcriptome sequencing was used to evaluate the molecular mechanism of the insecticidal activities. The results presented in this study should be useful for developing compound 2 as a novel, ecofriendly and safe biopesticide.
Highlights
Helicoverpa armigera (Hübner) is recognized as a polyphagous and cosmopolitan insect pest and has a high damage potential for various economically important crops around the world, including cotton, corn, tomatoes, sorghum, soybeans, and tobacco [1]
H. armigera in a acetate preliminary screening assay
0.3 mg/mL), prompting armigera in a preliminary screening assay, us to perform an in-depth analysis of the bioactive secondary metabolites present in it
Summary
Helicoverpa armigera (Hübner) is recognized as a polyphagous and cosmopolitan insect pest and has a high damage potential for various economically important crops around the world, including cotton, corn, tomatoes, sorghum, soybeans, and tobacco [1]. Some biological characteristics, such as polyphagy, mobility, fecundity, and facultative diapauses, can increase the survival and population outbreaks of the pest in agroecosystems [2]. Japan, China, and Southeast Asia [3] Owing to their biological characteristics and high damage. H.H. armigera is is largely dependent on on chemical pesticides [4]. Currently,the theprevention preventionand andcontrol controlofof armigera largely dependent chemical pesticides
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