Insect Nicotinic Acetylcholine Receptors

Abstract

1. Identification of Cholinergic Synaptic Transmission in the Insect Nervous System Steeve Herve Thany, Helene Tricoire?Leignel and Bruno Lapied Abstract Introduction Insect Acetylcholinesterase: Catalytic Properties and Tissue Distribution Identification and Tissue Distributions of Choline Acetyltransferase in Insects Identification of Native Neuronal Nicotinic Acetylcholine Receptors Insect Nicotinic Acetylcholine Receptors Subunit Localizations Conclusion 2. The Evolution of Pentameric Ligand?Gated Ion Chanels Joseph A. Dent Abstract Introduction Structure: pLGICs share an underlying structure Function: pLGICs Can Mediate Many Types of Ionotropic Neurotransmission Evolution: pLGIC Diversity Appears To Be Ancient What Good is pLGIC Diversity? 3. Diversity of Insect Nicotinic Acetylcholine Receptor Subunits Andrew K. Jones and David B. Sattelle Abstract Introduction Nicotinic Acetylcholine Receptors (nAChRs)-Structure and Function Nicotinic Acetylcholine Receptors-Roles in Human Disease and as Drug Targets Insect Nicotinic Acetylcholine Receptors-Targets for Pest Control The nAChR Gene Family in a Genetic Model Organism, the Fruitfly Drosophila melanogaster Characterisation of Complete nAChR Gene Families from Five Insect Species Spanning Over 300 Million Years of Evolution RNA Editing and Alternative Splicing Broadens the Insect Nicotinic Recepterome Conclusion and Prospects 4. Identification of Critical Elements Determining Toxins and Insecticide Affinity, Ligand Binding Domains and Channel Properties Helene Tricoire?Leignel and Steeve Herve Thany Abstract Introduction Toxins-nAChRs Interaction Insecticides-nAChRs Interaction: Residues Involved in Neonicotinoid Selectivity Insecticides-nAChRs Interaction: Residues Involved in Neonicotinoid Binding Amino?Acid Involved in Ionic Selectivity Conclusion 5. Electrophysiological Studies and Pharmacological Properties of Insect Native Nicotinic Acetylcholine Receptors Steeve HerveThany Abstract Introduction Pharmacological Profiles of Native Nicotinic Receptors Associated to Specific Neurons Contribution of 'Mixed' Nicotinic/Muscarinic Receptor to the Complexity of Native Nicotinic Receptors Ca2+ and Ca2+ Pathways as Intracellular Regulators of Insect Neuronal Nicotinic Receptors Other Modulators of Insect Native Nicotinic Acetylcholine Receptors Conclusion 6. Characterisation of Insect Nicotinic Acetylcholine Receptors by Heterologous Expression Neil S. Millar and Stuart J. Lansdell Abstract Introduction Characterization of Insect nAChRs by Heterologous Expression Characterization of Hybrid nAChRs Characterization of Chimeric nAChR Subunits Co?Expression of Molecular Chaperones Pharmacological Properties of Recombinant nAChRs Conclusion 7. Neonicotinoid Insecticides: Historical Evolution and Resistance Mechanisms Steeve Herve Thany Abstract Introduction Nicotine, Nicotinoids and Insecticidal Activities Neonicotinoid Insecticides Development of Novel Neonicotinoid Insecticides Multiple Origins of Insect Resistance to Neonicotinoid Insecticides Conclusion 8. Ecotoxicity of Neonicotinoid Insecticides to Bees Axel Decourtye and James Devillers Abstract Introduction Effects on Survival Behavioral Effects Conclusion 9. State of the Art on Insect Nicotinic Acetylcholine Receptor Function in Learning and Memory Monique Gauthier Abstract Introduction Role of ACh and Nicotinic Acetylcholine Receptors in Insect Behavior Role of Nicotinic Acetylcholine Receptors in Learning and Memory in the Honeybee Conclusion and Outlook: Using RNA Interference to Create Reversible Mutant Honeybees for Memory Index