Abstract
Abstract Rachel Carson’s Silent Spring (1962) dramatically focused public policy on the adverse effects of the indiscriminate and excessive use of inorganic and synthetic organic insecticides. The main concern was that these insecticides lacked selective activity - they were general biocides and, thus, toxic to most animal life. This event stimulated research to find alternative methods of chemical pest control, which eventually resulted in the discovery of chemistries possessing greater selectivity towards insects. One of the earliest successes from this activity was the discovery and development of insect growth regulators (IGRs) possessing very low mammalian toxicity.
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