Abstract
AbstractSeventeen 1,5‐disubstituted imidazoles possessing a variety of substituents were tested on Bombyx mori and Oncopeltus fasciatus. All compounds induced precocious metamorphosis from 4th‐instar larvae of B. mori. Of the compounds tested, 1‐benzyl‐5‐[(E)‐2,6‐dimethyl‐1,5‐heptadienyl]imidazole (KK‐42) was the most active against B. mori larvae. However, none of the compounds induced precocious metamorphosis in O. fasciatus nymphs, although several showed delayed toxicity. Treated nymphs died during or immediately after the moult. A series of 1‐isobutylimidazoles exhibited high activity against O. fasciatus, whereas KK‐42 was inactive even at high doses. There was no apparent correlation between the ability of imidazoles to cause precocious metamorphosis in B. mori and the delayed toxicity for O. fasciatus.
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