Inquiry on clinical application value of NLR and PLR in chronic obstructive pulmonary disease

Abstract

Objective To explore the clinical value of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) in chronic obstructive pulmonary disease (COPD), and compared with C-reactive protein (CRP). Methods In this study, the clinical data of 157 patients with clear diagnosis of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) were enrolled, and their stable period (SCOPD) data were collected.The clinical data, which were collected from 146 patients of health examination in Pukou Branch, Jiangsu Province Hospital, were randomly taken as the reference group.To explore the value of NLR and PLR in predicting the risk of acute exacerbation of COPD and investigate the correlation between the NLR, PLR and the lung function of COPD patients. Results (1)Compared with the healthy control group and the SCOPD group, the NLR (H=164.205, P 0.05), PLR (H=5.614, P>0.05) and CRP (H=3.909, P>0.05) index among patients with Ⅰ-Ⅳ COPD. Conclusions NLR, PLR and CRP levels have high diagnostic value for AECOPD, and NLR and CRP have similar diagnostic accuracy.There is no significant correlation between lung function severity in patients with NLR, PLR, and COPD. Key words: Pulmonary disease, chronic obstructive; C-reactive protein; Neutrophil-lymphocyte count ratio; Platelet to lymphocyte ratio