Proceedings of the National Academy of Sciences | VOL. 119

Input-specific control of interneuron numbers in nascent striatal networks

Publication Date May 9, 2022


Significance Brain function requires appropriate numbers of different neuronal subtypes, but how these numbers are established remains poorly understood. Here, we identified a key role for the cerebral cortex in remotely controlling interneuron survival and thus establishing appropriate numbers of the two main types of interneurons in another brain region, the striatum. While cortical pyramidal cells directly control the survival of parvalbumin-expressing GABAergic neurons, the survival of cholinergic interneurons is indirectly controlled through the activity of the striatal medium spiny neurons. Our results demonstrate that the input-specific modulation of neuronal activity is universally required to control the survival of interneurons across very different brain circuits. This is important for the assembly of balanced neural networks.


Survival Of Interneurons Neuronal Subtypes Brain Circuits Parvalbumin-expressing Neurons Assembly Of Networks Brain Region Balanced Networks Survival Of Neurons Modulation Of Activity Activity Of Neurons

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