Abstract

The contractile strength of isolated rabbit heart is dependent on the Ca 2+ concentration in the perfusion medium. At suboptimal Ca 2+ concentration, the addition of exogenous phospholipids extracted from beef heart improves myocardial contractility. Evidence is presented that phospholipids significantly potentiate the inotropic effect of digitoxin. The possible mechanism by which phospholipids facilitate Ca 2+ transport is discussed.

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