Abstract
Microinjection of inositol 1,3,4,5-tetrakisphosphate or inositol 1,4,5-trisphosphate induced distinct chloride membrane currents in defolliculated Xenopus laevis oocytes. To decide whether these Cl −-currents were due to the injected compounds or their metabolic products, [ 3H]Ins(1,3,4,5)P 4 or [ 3H]Ins(1,4,5)P 3 were injected into oocytes and their metabolites were analyzed by HPLC. Our results indicate that Ins(1,3,4,5)P 4 itself or its metabolite Ins(1,3,4,6)P 4 is able to induce Cl −-membrane currents, most likely by increasing the cytosolic Ca ++-concentration.
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