Abstract
The hydrolysis of [ 3H]inositol 1,4,5-trisphosphate by a soluble fraction and by isolated transverse tubule and sarcoplasmic reticulum membranes from frog skeletal muscle was studied. Transverse tubule membranes displayed rates of hydrolysis several-fold higher than those of sarcoplasmic reticulum and soluble fraction; K m and V max were 25.2 μM and 44.1 nmol/mg/min, respectively. Transverse tubule membranes sequentially hydrolyzed inositol trisphosphate to inositol bisphosphate, inositol 1-phosphate and inositol. Indicating that these membranes have inositol bis- and monophosphatases in addition to inositol trisphosphatase.
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