Abstract
Inosine 5’-monophosphate, EC 1.1.1.205 (IMPDH) catalyzes the conversion of IMP to XMP utilizing NAD as a proton acceptor. Its role in catalyzing the rate determining step in the biosynthesis of GTP1 gives IMPDH a position of central importance in cellular activity because of the myriad activities of GTP in biosynthesis and cellular regulation. The activity of IMPDH is much higher in proliferating tissues, both normal and malignant 2, 3 suggesting that the salvage of guanine by hypoxanthine-guanine phosphoribosyltransferase is probably inadequate to satisfy the requirements of dividing cells for guanine nucleotides.
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