Abstract
Red cell structure and function were examined in rats exposed to 80% oxygen : 20% nitrogen for five days and compared with red cells from air-breathing animals. Evidence of red cell destruction was noted in the animals exposed to hyperoxia. Osmotic fragility was found to be reduced in red cells from oxygen exposed rats ( p < 0.05), also, red cell haemolysis in hydrogen peroxide was noted to be greater ( p < 0.001) in these animals. Inorganic phosphate ion transport was significantly reduced ( p < 0.001) in the red cells from rats receiving oxygen for 5 days. The results demonstrate a decreased ability of the red cell to transport anions and suggest an impairment of the normal movement of water across the membrane following exposure to oxygen.
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