Abstract
Many human diseases are inflammation-related, such as cancer and thoseassociated with aging. Previous studies demonstrated that plasmon-induced activated(PIA) water with electron-doping character, created from hot electron transfer viadecay of excited Au nanoparticles (NPs) under resonant illumination, owns reducedhydrogen-bonded networks and physchemically antioxidative properties. In this study,it is demonstrated PIA water dramatically induced a major antioxidative Nrf2 gene in human gingival fibroblasts which furtherconfirms its cellular antioxidative and anti-inflammatory properties. Furthermore,mice implanted with mouse Lewis lung carcinoma (LLC-1) cells drinking PIA wateralone or together with cisplatin treatment showed improved survival time compared tomice which consumed only deionized (DI) water. With the combination of PIA water andcisplatin administration, the survival time of LLC-1-implanted mice markedlyincreased to 8.01 ± 0.77 days compared to 6.38 ± 0.61 days of mice given cisplatinand normal drinking DI water. This survival time of 8.01 ± 0.77 days compared to4.62 ± 0.71 days of mice just given normal drinking water is statisticallysignificant (p = 0.009). Also, the grossobservations and eosin staining results suggested that LLC-1-implanted mice drinkingPIA water tended to exhibit less metastasis than mice given only DI water.
Highlights
University, No 250, Wuxing St., Taipei, 11031, Taiwan
Since plasmon-induced activated (PIA) water exhibited anti-inflammatory activity in vitro, a preclinical mouse disease model is worthy of further study to evaluate the anti-inflammatory potential of PIA water in the chronic inflammation-related disease of non-small cell lung cancer (NSCLC)
The unique ability to scavenge free hydroxyl radicals and other distinct properties of PIA water compared to deionized (DI) water may offer a new therapy for suppressing inflammation and even for curing cancer
Summary
University, No 250, Wuxing St., Taipei, 11031, Taiwan. Chien-Kai Wang, Hsiao-Chien Chen and Sheng-Uei Fang contributed to this work. The previous study indicated that PIA water produced by AuNPs can reduce NO release by LPS-treated monocytes[15] This finding suggested that PIA water has in vitro antioxidative activity to prevent oxidative stress induced by acute inflammation. Since PIA water exhibited anti-inflammatory activity in vitro, a preclinical mouse disease model is worthy of further study to evaluate the anti-inflammatory potential of PIA water in the chronic inflammation-related disease of non-small cell lung cancer (NSCLC). To explore potential clinical applications of PIA water in NSCLC therapy, a transpleural orthotopic mouse model using Lewis lung cancer-1 (LLC-1) cells (a cell line originally isolated from C57BL/6 mice) was applied to examine the antitumor effects of PIA water on LLC-1-implanted mice. This study may provide useful information to explore probable clinical applications of PIA water
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