Abstract
Solid contact potentiometric sensors for trazodone hydrochloride based on host-guest interactions and potentiometric transduction has been designed and characterized.The sensorsare produced via preparation of trazodone hydrochloride imprinted polymer particles using methacrylic acid and acrylonitrile as functional monomers. Subsequently, the leached molecularly imprinted polymer (MIP) particles were dispersed in dioctylphathalateand embedded in polyvinyl chloride matrix.The results of the MIP sensors show that they offered an improved electrode slope, pH wide range and anextremelyprolonged life time reaching 4 months in comparison toconventional ion-exchangers reported in literature.Significantly, these simple and cost-effective potentiometric sensors promote accuracy, precision, good reproducibility, selectivity, sensitivity and long-term stability. There is no interference from any common excipients and additives present in pharmaceutical preparation sothe proposed methods promote the global use of appropriate quality, safety assaying of pharmaceutical dosage form in tablets.
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