Innovation status of gene therapy for breast cancer.

Maricruz Anaya-Ruiz,Martin Perez-Santos

doi:10.7314/apjcp.2015.16.9.4133

Maricruz Anaya-Ruiz, Martin Perez-Santos

Open Access

https://doi.org/10.7314/apjcp.2015.16.9.4133

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Abstract

To analyze multi-source data including publications and patents, and try to draw the whole landscape of the research and development community in the field of gene therapy for breast cancer. Publications and patents were collected from the Web of science and databases of the five major patent offices of the world, respectively. Bibliometric methodologies and technology are used to investigate publications/patents, their contents and relationships. A total of 2,043 items published and 947 patents from 1994 to 2013 including "gene therapy for breast cancer" were retrieved. The top five countries in global publication share were USA, China, Germany, Japan and England. On the other hand, USA, Australia, England, South Korea and Japan were the main producers of patents. The universities and enterprises of USA had the highest amount of publication and patents. Adenovirus- and retrovirus-based gene therapies and small interfering RNA (siRNA) interference therapies were the main topics both in publications and patents. The above results show that global research in the field of gene therapy for breast cancer is increasing and the main participants in this field are USA and Canada in North America, China, Japan and South Korea in Asia, and England, Germany, and Italy in Europe. Also, this article demonstrates the usefulness of bibliometrics to address key evaluation questions and define future areas of research.

Highlights

Breast cancer remains a major public health problem
The global publication share of top 15 most productive countries in gene therapy for breast cancer is shown in Table 1, with USA occupying the first rank and contributing the largest publication share (48.02%), followed by China (16.25%, 2nd rank), Germany (7.73%, 3rd rank), Japan (7.05%, 4th rank), England (5.58, 5th rank), Canada, Italy, France, South Korea and Spain, Netherlands, Switzerland, Finland, Australia and Sweden
The global publication share has witnessed the largest increase of 31.69% in China, followed by South Korea (3.69%), Spain (1.63%), Netherlands (1.55%), Finland (1.1%), Table 2

Summary

Introduction

Breast cancer remains a major public health problem. Currently, among all cancers, breast cancer is the most common cancer in women in both developed and developing countries (Anaya-Ruiz et al, 2014; Dogan and Toprak, 2014; Shi et al, 2014; Malvezzi et al, 2014; Youlden et al, 2014). Extensive research has been conducted to solve the problem of breast cancer, but the remedy still remains uncertain Faced with this dilemma, scientific research evaluation has as purpose monitoring of ongoing research initiatives to assess the efficiency and effectiveness with which they are being implemented, and to determine the extent to which they are achieving their targeted objectives, and to recommend adjustments. Conclusions: The above results show that global research in the field of gene therapy for breast cancer is increasing and the main participants in this field are USA and Canada in North America, China, Japan and South Korea in Asia, and England, Germany, and Italy in Europe.

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