Abstract

in the literature that ectopic acromegaly is more often seen in women younger than 40 years. Unfortunately, the neuroendocrine tests cannot differentiate between ectopic GHRH secretion and pituitary adenoma. High GH plasma levels and excessive production of GHRH can be suggestive of ectopic secretion, with the exception of very rare cases of excessive GHRH of hypothalamic origin. The somatostatin receptor scintigraphy could have been an alternative diagnostic tool, but it was not performed in our case. In inoperable cases or incomplete operations, octreotide seems to be effective. Surgical excision of the bronchial carcinoid tumor leads to a rapid decrease of GHRH and to a benign clinical course, as is also mentioned in other reports.

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