Innentitelbild: Modular Synthesis of a Tridecasaccharide Motif of Bacteroides vulgatus Lipopolysaccharides against Inflammatory Bowel Diseases through an Orthogonal One‐Pot Glycosylation Strategy (Angew. Chem. 22/2023)

Abstract

Lipopolysaccharides from Bacteroides vulgatus represent interesting targets for the treatment of inflammatory bowel diseases. In their Research Article (e202301351), Guozhi Xiao and co-workers accomplished the first synthesis of a tridecasaccharide motif from Bacteroides vulgatus lipopolysaccharides by a strategy involving orthogonal one-pot glycosylation reactions based on glycosyl ortho-(1-phenylvinyl)benzoates, which precluded issues such as aglycone transfer and the unpleasant odor of thioglycoside-based orthogonal one-pot glycosylation.