Abstract
Antibody dynamics on membranes, such as endocytosis and clustering, are vital in determining antibody functions. Yoshiyuki Manabe, Kazuya Kabayama, Koichi Fukase et al. proposed a new approach to modulate antibody dynamics and its function. In their Communication (e202304779), the antibody was conjugated with galactose-containing N-glycan, and its internalization was suppressed by the interaction with galectin-3, leading to the enhancement of complement-dependent cytotoxic (CDC) activity. The glycan–antibody conjugate might provide an alternative strategy for enhancing antibody activity.
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