Innenrücktitelbild: Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition (Angew. Chem. 32/2023)

Abstract

O-fucosylated glycan epitopes of membrane-bound mucin glycoproteins are key ligands of many bacterial lectins. In their Research Article (e202302437), Ulrika Westerlind and co-workers describe the synthesis of fucosylated mucin glycopeptides using a chemoenzymatic approach. Starting from simple building blocks, Fmoc-protected glycosylated amino acids were prepared and incorporated into peptides and enzymatically diversified. Bacteria lectin interactions were then elucidated on glycopeptide microarrays.