Abstract
The importance of innate immune cells in cancer promotion has been long recognized. Luci etal. (2021) show a key role for innate lymphoid cells (ILCs) in controlling precancerous skin lesions and impaired function of NK cells and ILC1s during progression to cutaneous squamous cell carcinoma (cSCC). These results, together with other findings, suggest that activation of ILCs could serve as a novel immunotherapeutic strategy against cSCC.
Highlights
Cutaneous squamous cell carcinoma is the second most common cancer, with a significant rise in its incidence over the last decade (Que et al, 2018)
Using skin chemical carcinogenesis and murine cutaneous squamous cell carcinoma (cSCC) cell line graft models, they showed a requirement for NK cells at a precancerous stage for protection against early cSCC development
On the basis of Luci et al (2021) and other publications, the enrichment of ILC2s in healthy skin versus the high infiltration of ILC1s in the precancerous papilloma stage indicates a potential plasticity in ILC regulation in the skin that may evolve from one subtype to another in Targeting innate lymphoid cells (ILCs) in precancerous skin lesions provides an opportunity to prevent cutaneous squamous cell carcinoma development
Summary
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with a significant rise in its incidence over the last decade (Que et al, 2018). Using skin chemical carcinogenesis and murine cSCC cell line graft models, they showed a requirement for NK cells at a precancerous stage for protection against early cSCC development.
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