Abstract
ObjectivesPathogenesis of avascular osteonecrosis of the femoral head (ONF) still remains unclear. We hypothesized that innate immune signaling via toll‐like receptor (TLR) play any role in pathogenesis of ONF. We found that administration of ligands of TLR with steroid treatment induces ONF. The present study verified the hypothesis and evaluated effect of steroid in the development of the ONF.MethodsMale Wistar rats (n=120) were randomly divided six groups. Each group rats were given saline or ligands of TLR on day 1 and saline or methylprednisolone on day 2. Animals were sacrificed 1, 3, 7 or 14 days after last injection. Histopathological, biochemical analyses were then performed.ResultsONF was observed in groups given ligands of TLR and methylprednisolone treatment. Although the activity of IRF7 did not change, the activity of NF‐κB was decreased after methylprednisolone injection.ConclusionsThe present study shows that the innate immunity signaling pathway via the TLR, especially MyD88 dependent pathway may play a crucial role in pathogenesis of ONF.
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