Abstract
Meeting abstracts Spontaneous T cell responses against tumors occur frequently. However, the mechanisms by which innate immune responses become induced in response to cancer, and how they can bridge to T cell priming against tumor antigens, have been poorly understood. We recently showed that CD11c
Highlights
We recently showed that CD11c+ cells produce IFN-b after tumor implantation and this IFN-b plays a critical role in cross-priming of endogenous anti-tumor CD8+ T cells in vivo
Using knockout mice lacking candidate innate immune sensing molecules known to be able to induce type I IFN production in APCs, we have identified a critical role for the host STING pathway in tumor recognition, spontaneous T cell priming, and tumor control in vivo
Tumor-infiltrating CD45+CD11c+ cells were analyzed by ImageStream single cell cytometry
Summary
Spontaneous T cell responses against tumors occur frequently. The mechanisms by which innate immune responses become induced in response to cancer, and how they can bridge to T cell priming against tumor antigens, have been poorly understood. We recently showed that CD11c+ cells produce IFN-b after tumor implantation and this IFN-b plays a critical role in cross-priming of endogenous anti-tumor CD8+ T cells in vivo.
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