Abstract
African catarrhine primates differ in bacterial disease susceptibility. Human, chimpanzee, and baboon blood were stimulated with TLR-detected bacterial agonists and cytokine/chemokine induction assessed by real-time PCR. Humans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent. These primates tend to generate species rather than agonist-specific responses to bacterial agonists.
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