Abstract
MW Hall, SM Geyer, CY Guo; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network PICFlu Study Investigators. Crit Care Med. 2013;41(1):224–236 The influenza virus can inhibit leukocyte function in vitro and in vivo, and is associated with severe secondary bacterial infections. Immunoparalysis is the state marked by reduction in the ability to produce tumor necrosis factor (TNF)-α in response to lipopolysaccharide (LPS). This study sought to test the hypothesis that mortality from influenza in critically ill children and young adults is associated with both hypercytokinemia and innate immune suppression. Patients <18 years old, who were admitted to 1 of the 15 PICUs that belong to the Pediatric Acute Lung …
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