Innate cellular immune responses in experimental animals of different age on the background of inflammation and the introduction of immunomodulators

Abstract

Topicality. Insufficient light in the world scientific literature the problem of changing the regulatory mechanisms of the immune response depending on age. Little-studied molecular events and cellular interactions underlying the mechanisms of immunoreactivity for the development of adaptation at different stages of ontogenesis.Aim. To study peculiarities of changes of phagocytic activity of neutrophils and evaluation of their enzymatic activity in the experimental animals of different ages on the background of inflammatory process and the use of immunocorrectjrs polioksidonium and mixfactor.Materials amd methods. In the course of work conducted the study of the cellular component of innate immunity in experimental animals of different ages on the background of the introduction of a suspension of E. coli and the use of immunomodulators at different stages of the experiment by microscopic method.Results and discussion. The study revealed that polioksidonium should be applied after the activation of the inflammatory response since this drug has a pronounced antioxidant activity, which is negative to ensure the phagocytosis of neutrophils through reactive oxygen species, which provides endotsitoz bacterial antigens.Conclusions. The introduction of an experimental composite preparation mixfactor resulted in stimulation of phagocytosis activity, which is evidence about adaptive interaction processes of reactivity and resistance of experimental animals of different age.