Abstract
Recent advances in inkjet-printing of advanced materials have provided a versatile platform for the rapid development and prototyping of sensor devices. We have recently demonstrated inkjet-printed surface enhanced Raman scattering (SERS) sensors on flexible substrates for the detection of variety of small molecules [Tay et al. in Front Chem 9:680556 (2021); Tay et al. in J Raman Spectrosc 52:563 (2020)]. These flexible SERS sensors have many advantages for performing point-of-sampling testing, among them liquid or aerosol filtration and swabbing capabilities. These simple sampling and separation features make these inkjet-printed paper-based sensors ideal for field applications. SERS detection of molecules with poor binding affinity towards the plasmonic surfaces of the sensors tends to be inefficient. A surface functionalization approach has been applied to SERS sensors to improve the molecule affinity and hence their detection sensitivity. In this paper, we investigate the optimization of SERS sensor fabrication to achieve optimal performance. Three performance criteria: diffuse reflectance, SERS background intensity from the as-printed blank sensors and SERS performance of sensors exposed to the benzenethiol reporter molecule, are characterized carefully to derive the optimal inkjet-printing conditions for producing the best performing SERS sensors. Additionally, we demonstrate the use of a simple potassium iodide functionalization scheme to improve the detection sensitivity for narcotics such as fentanyl by two orders of magnitude.Graphical abstract
Highlights
Fentanyl is a potent synthetic opioid originally developed for pain relief and management of severe pain such as, for example, in cancer patients
This is extremely important as the majority of the surface enhanced Raman scattering (SERS) signals are generated from aggregated Au nanoparticles (AuNP) which sustains strong field enhancements upon resonant optical excitation
We have examined the use of the receiver operating characteristic (ROC) method to better understand the binary quantification of the inkjet-printed SERS sensors [20]
Summary
Fentanyl is a potent synthetic opioid originally developed for pain relief and management of severe pain such as, for example, in cancer patients. We have recently demonstrated inkjet-printed surface enhanced Raman scattering (SERS) sensors on flexible substrates for the detection of small chemical molecules [16, 17].
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