Injury of aldehyde dehydrogenase 2 in organ ischemia-reperfusion injury through autophagy

Abstract

With the rapid development of organ transplantation in China, the donation after cardiac death (DCD) donor organs are widely used. However, the quality of these organs is relatively poor, so the way to preserve and maintain organ still remains a severe problem. Among them, ischemic reperfusion injury (IRI) impairs the organs severely. Acetaldehyde dehydrogenase 2 (ALDH2) protects organs from stress conditions, including ischemia-reperfusion injury, and the activation and autophagy inhibition also protects the organs from stress conditions as well. Recent studies showed that ALDH2 can regulate autophagy to inhibit the organ injury during ischemia-reperfusion. Our study aims to discuss the new findings in this mechanism. Key words: Autophagy; Donation after cardiac death; Aldehyde dehydrogenase 2; Reperfusion injury; Maintenance and restoring