Abstract
The underlying molecular mechanisms for the association between aging and a higher susceptibility to develop ARDS are poorly understood. The pulmonary renin-angiotensin system (RAS), with a lung-protective (angiotensin-converting enzyme (ACE)2-angiotensin (Ang)-1,7-Mas receptor) axis and a lung-injurious (ACE-Ang II-Ang II receptor (AT1)) axis, has been implicated in the pathogenesis of ARDS and changes with age. We hypothesized that injurious ventilation has an age-dependent effect on the pulmonary RAS in LPS-challenged rats that is associated with increased lung injury.
Highlights
We aimed to audit the prescribing practice on a busy 14-bedd general ICU, and develop standardised practices and tools to improve safety
Pediatric pharmacists have been an integral part of the PICU rounds since 2002, their role has evolved over the course of years
From 1 January 2003 through 31 December 2012 pharmacists made 24,207 clinical interventions in the PICU and 19,252 of those interventions resulted in changes in medication therapy or therapy monitoring
Summary
We aimed to audit the prescribing practice on a busy 14-bedd general ICU, and develop standardised practices and tools to improve safety. The objective of our study was to implement a Post Arrest Consult Team (PACT) and improve the quality of care for admitted OHCA patients This retrospective audit evaluated adult patients who suffered in-hospital cardiac arrest (IHCA) against the recent National Confidential Enquiry into Patient Outcome and Death (NCEPOD) report [1]. It looked at the recognition of the acutely unwell, the interventions made, the decisions taken from admission through to the post-arrest period and the outcomes following cardiopulmonary resuscitation (CPR). Methods We conducted a chart review of all patients admitted to the Department of Critical Care (DCC) at our hospital following cardiac arrest over 2 years in 2010 to 2012 (Group 1). Methods A retrospective review was conducted looking at SICU patients managed with a normothermia protocol, with particular
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