Abstract
Recently we became aware of an association between the administration of a large amount, 72 mg, of a vitamin-K analogue (menadione sodium bisulfite, Hykinone®) intravenously to mothers in labor and the occurrence of marked, early hyperbilirubinemia in newborn premature infants. We have encountered seven such cases, the details of which are listed in the Table. These infants were first noted to have markedly elevated levels of bilirubin in the serum between 40 and 72 hours of age. All but one were treated with exchange transfusion in an effort to prevent neurologic damage (kernicterus) from hyperbilirubinemia.
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