Injection of Enriched Hyaluronic Acid for Vaginal Dryness in a Tamoxifen User

Abstract

Studies indicate that > 90% of breast cancer survivors taking adjuvant endocrine therapy as tamoxifen experience menopausal symptoms, including vaginal dryness and dyspareunia. Unfortunately, these sexual problems are closely related to depression and early discontinuation of treatment. The injectable use of cross-linked Hyaluronic Acid (HA) gel in the vaginal walls has demonstrated encouraging results in improving the symptoms of vaginal dryness but it was associated with non-thrombotic pulmonar embolism. We report the case of a young female patient, 39 years old, using tamoxifen for 4 years for preventing breast cancer recurrence, with vaginal dryness and dyspareunia, whose injection of a liquid formulation, containing non-cross linked hyaluronic acid, antioxidants and amino acids brought significant clinical improvement of sexual concerns.