Abstract

Injectable thermoreversible poly(amino acid) hydrogels have been developed. Amphiphilic poly(α/β-asparagine) derivatives, synthesized by the reaction of polysuccinimide with a combination of hydrophilic and hydrophobic amines, showed a sharp sol–gel–sol transition in an aqueous solution. The transition temperature could be controlled by the side-chain structure of the poly(amino acid)s.

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