Abstract
ObjectiveTo investigate the usefulness of addition type liquid silicone rubber (ATLSR) as injectable implant after evisceration to maintain the eyeball volume in an animal experiment.MethodsTwelve adult New Zealand white rabbits were included. One eye of each rabbit was randomly selected for evisceration with the fellow eye as control. ATLSR was injected to fill the eyeball socket after evisceration. In vivo observation and photographs were performed up to 24 weeks post-op. Two rabbits were sacrificed respectively at post-operative week 1, 2, 4, 8, 12 and 24. After enucleation, the vertical, horizontal and sagittal diameters of the experimental eyeballs were measured and compared with the control eyes. Histopathological studies were performed to evaluate signs of inflammation.ResultsCornea remained clear throughout the observation period despite mild epithelial edema and neovascularization. Compared to the control eyes, the experimental eyes were significantly smaller in vertical diameter (17.00±1.17 vs. 17.54±1.11 mm, P<0.001), but larger in sagittal diameter (16.85±1.48 vs. 16.40±1.38 mm, P = 0.008), and had no significant difference in horizontal diameter (17.49±1.53 vs. 17.64±1.21 mm, P = 0.34). Postoperative inflammation was observed at one week after surgery, which peaked at 2–3 weeks, then regressed gradually. At week 12 and week 24, most of the inflammatory cells disappeared with some residual plasma cells and eosinophils.ConclusionInjectable addition type silicon rubber may be a good choice for ocular implantation after evisceration, maintaining eyeball volume and cosmetically satisfactory when compared to the fellow eye. Spontaneous regression of inflammation implied good biocompatibility for at least 24 weeks.
Highlights
Removal of painful blind eyes, cosmetically unacceptable blind eyes, and medically uncontrolled endophthalmitis as a result of severe trauma or disease can be accomplished by either evisceration or enucleation [1,2]
Cornea remained clear throughout the observation period despite mild epithelial edema and neovascularization
Postoperative inflammation was observed at one week after surgery, which peaked at 2–3 weeks, regressed gradually
Summary
Removal of painful blind eyes, cosmetically unacceptable blind eyes, and medically uncontrolled endophthalmitis as a result of severe trauma or disease can be accomplished by either evisceration or enucleation [1,2]. Several surgical techniques have been described to achieve better appearance and prosthesis motility as well as less complications [13,14,15]. An ocular implant should preferably be placed in the cornea-scleral shell after the removal of the ocular contents (in-situ placement), which in turn results in improved appearance and prosthesis motility [16]. When mixed with the catalyzer, the monomer cross-links, solidifies, rending it easy to shape as well as physicochemically stable [20,21,22]. It has grown into a commonly used substance for making external prosthesis. We investigate the applicability of ATLSR as an injectable implant after evisceration to maintain the eyeball volume in an animal experiment
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
