Abstract
Developing methods for insulin delivery continues to be of great translational research interest as insulin remains one of the most effective and commonly used treatments for diabetes. Bolus insulin injection at frequent intervals or insulin-loaded pumps used to treat diabetic patients have drawbacks including highly uneven kinetics, low patient compliance, enhanced chances of infections and disease transmission, and device fouling. This study evaluates the in vivo effects of insulin-loaded, salicylate-based, biocompatible, biodegradable polymeric microspheres that gradually release salicylic acid and insulin simultaneously. The study is predicated on the knowledge that such a continuous delivery system can release insulin over an extended period of time and overcome the aforementioned issues. Additionally, salicylic acid reduces insulin resistance in type-2 diabetic patients. In this work, we observed that insulin and salicylic acid were detected in serum over an extended period of time (at least 12 h and 4 days, respectively), and mice receiving insulin-loaded microspheres had a blood glucose reduction time frame ⩾12 times that of bolus insulin administration.
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