Abstract
Chronic diabetic wounds are lack of angiogenesis and susceptible to bacterial infections due to their high sugar microenvironment, making them difficult to heal. Here, a conductive and intrinsically antibacterial hydrogel with pH responsiveness has been developed. This hydrogel has good mechanical properties, self-healing ability and biocompatibility, and can smartly release the pro-angiogenic drug, deferoxamine. Application of the hydrogel promotes the proliferation and migration of endothelial cells and enhances vascularization by upregulating the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor. The hydrogel dressing combined with electrical stimulation improves angiogenesis and significantly accelerates the healing of infected diabetic wounds, which would lead to a promising therapeutic strategy.
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