Injectable 2D Material-Based Sensor Array for Minimally Invasive Neural Implants.

Abstract

Intracranial implants for diagnosis and treatment of brain diseases have been developed over the past few decades. However, the platform of conventional implantable devices still relies on invasive probes and bulky sensors in conjunction with large-area craniotomy and provides only limited biometric information. Here, we report an implantable multi-modal sensor array that can be injected through a small hole in the skull and inherently spread out for conformal contact with the cortical surface. The injectable sensor array, composed of graphene multi-channel electrodes for neural recording and electrical stimulation and MoS2-based sensors for monitoring intracranial temperature and pressure, was designed based on a mesh structure whose elasticrestoringforce enables the contracted device to spread out. We demonstrated that the sensor array injected into a rabbit's head can detect epileptic discharges on the surface of the cortex and mitigate it by electrical stimulation while monitoring both intracranial temperature and pressure. This method providesgoodpotentialfor implanting a variety of functional devices via minimally invasive surgery. This article is protected by copyright. All rights reserved.