Abstract
In an attempt to induce experimental varicosity, reverse perforant vein development was initiated in the rat leg by applying a chronic (14 and 32 weeks) partial stricture on the main branch of the deep femoral vein. At surfacing of the incompetent perforantes, typical reticular vein plaques and spider veins were identified by video-microscopy and quantitative histology. Deep vein blood was channeled by them into the saphenous vein system, the extra flow deforming these vessels, causing local dilations and broken course, even undulations of larger branches.
Highlights
In an attempt to induce experimental varicosity, reverse perforant vein development was initiated in the rat leg by applying a chronic (14 and 32 weeks) partial stricture on the main branch of the deep femoral vein
Fourteen and 32 weeks after partial occlusion of the deep femoral vein, at reoperation, it was found that scar tissue fully closed the deep femoral veins at stricture site
Sufficient collaterals developed to prevent any venous tissue flow disturbance. Part of such collaterals were real reverse perforant veins (Fig. 1d) able to empty their blood into reticular vein plaques at the muscle surface (Fig. 1b)
Summary
In an attempt to induce experimental varicosity, reverse perforant vein development was initiated in the rat leg by applying a chronic (14 and 32 weeks) partial stricture on the main branch of the deep femoral vein. In a recent publication we reported that after chronic partial occlusion of the saphenous vein main branch of the rat, a rich collateral network developed, with morphological similarity to the reticular veins of the initial phase of the human leg varicosity disease. The resulting collateral venous network was studied by injection of methylene blue stained saline into the deep femoral vein and observing its appearance in the veins on the surface of the thigh and leg muscles. Their structure was examined after further microsurgical exploration by video-microscopy and on histological sections
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